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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOPBP1 All Species: 17.58
Human Site: S998 Identified Species: 55.24
UniProt: Q92547 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92547 NP_008958 1522 170679 S998 H T Y N P K M S L D I S A V Q
Chimpanzee Pan troglodytes XP_516761 1587 177009 S1063 H T Y N P K M S L D I S A V Q
Rhesus Macaque Macaca mulatta XP_001112636 1622 181547 S1098 H T Y N P K M S L D I S A V Q
Dog Lupus familis XP_534266 1697 189421 S1173 H T Y N P K M S L D I S T V Q
Cat Felis silvestris
Mouse Mus musculus Q6ZQF0 1515 168842 S1000 H T Y N P K M S L D I N T V Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524909 1425 158421 E933 M R E N Q T P E L E R I R R Q
Honey Bee Apis mellifera XP_394416 1192 134009 M700 K P N G T N N M N I T S N K T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_788169 651 72132 K159 P A T P L A P K Q P P P I E K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.4 91.8 81.1 N.A. 76.8 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 25.2 21.1 N.A. 21.4
Protein Similarity: 100 95.6 93.1 85 N.A. 85.7 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 44.1 38.5 N.A. 30
P-Site Identity: 100 100 100 93.3 N.A. 86.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 20 6.6 N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 26.6 6.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 0 0 0 13 0 0 0 0 0 0 38 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 % D
% Glu: 0 0 13 0 0 0 0 13 0 13 0 0 0 13 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 13 63 13 13 0 0 % I
% Lys: 13 0 0 0 0 63 0 13 0 0 0 0 0 13 13 % K
% Leu: 0 0 0 0 13 0 0 0 75 0 0 0 0 0 0 % L
% Met: 13 0 0 0 0 0 63 13 0 0 0 0 0 0 0 % M
% Asn: 0 0 13 75 0 13 13 0 13 0 0 13 13 0 0 % N
% Pro: 13 13 0 13 63 0 25 0 0 13 13 13 0 0 0 % P
% Gln: 0 0 0 0 13 0 0 0 13 0 0 0 0 0 75 % Q
% Arg: 0 13 0 0 0 0 0 0 0 0 13 0 13 13 0 % R
% Ser: 0 0 0 0 0 0 0 63 0 0 0 63 0 0 0 % S
% Thr: 0 63 13 0 13 13 0 0 0 0 13 0 25 0 13 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 63 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 63 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _